1. Revolutionary War Battle of Ninety Six: On April 19, 1781, the Battle of Ninety Six began in South Carolina during the Revolutionary War. British forces, under the command of Lieutenant Colonel John Cruger, were besieged by American forces led by Major General Nathanael Greene. The battle lasted for 28 days and resulted in a British victory.

2. Charleston Slave Auctions: April 19, 1856, marks the date of one of the largest slave auctions in Charleston history. Slaves were purchased and sold at the Ryan and Peterson auction house, and around 450 slaves were sold in a single day.

3. Clemson University's Founding: On April 19, 1889, South Carolina Governor John Peter Richardson signed a bill that established Clemson Agricultural College, which is now Clemson University. The school was founded through a bequest from Thomas Green Clemson, who had donated his estate to create the college.

4. The Great Charleston Earthquake: On April 19, 1886, an earthquake of magnitude 7.3 hit South Carolina. The earthquake was centered near Charleston and caused extensive damage to buildings and infrastructure in the city. It was the most destructive earthquake ever to hit the southeastern United States.

5. Fort Sumter: On April 19, 1861, the American Civil War began when Confederate forces fired on Fort Sumter in Charleston Harbor. The fort was held by Union forces, and the attack marked the first military action of the war. After a 34-hour bombardment, the fort surrendered to the Confederates.