1. On April 22, 1889, the first issue of The Daily Clarion-Ledger, a newspaper based in Jackson, Mississippi, was published. Over the years, the paper has become one of the most respected news sources in the state.

2. On April 22, 1960, the first heart transplant in Mississippi was performed at the University of Mississippi Medical Center. The patient, a 57-year-old man, survived for two days before dying of complications.

3. April 22, 1970, was the very first Earth Day, an annual event celebrated around the world to raise awareness about environmental issues. The day is marked by conferences, rallies, and other activities geared toward promoting environmental conservation and sustainability.

4. On April 22, 1998, tornadoes swept through central Mississippi, killing five people and causing widespread damage. The tornado outbreak was one of the deadliest in Mississippi history, and the damage totaled over $40 million.

5. April 22, 2010, marked the first anniversary of the Deepwater Horizon oil spill, one of the worst environmental disasters in US history. The spill began on April 20, 2010, when an explosion on the drilling rig killed 11 workers and set off a chain reaction of events that resulted in the discharge of millions of barrels of oil into the Gulf of Mexico. The spill had a lasting impact on Mississippi's coastal regions and marine ecosystems, and efforts to restore the area are ongoing.