1. The first game of what would become the Boston Marathon took place on April 19, 1897. It was organized by the Boston Athletic Association and featured 15 participants who ran a 24.5-mile course from Metcalf's Mill in Ashland to the B.A.A. clubhouse in Boston. Today, the Boston Marathon is one of the most prestigious and well-attended marathons in the world.

2. On April 6, 1869, the first paper money to feature a portrait of a woman was issued by the U.S. Treasury. The note, known as a "Legal Tender Note," featured a portrait of Martha Washington on the face side. Martha Washington was the wife of George Washington, the first President of the United States, and is considered an important figure in American history in her own right.

3. The Salem Witch Trials, one of the most infamous episodes in Massachusetts history, began in earnest on April 6, 1692, when two women were arrested on charges of witchcraft. Over the next several months, dozens more would be accused and imprisoned, and 19 would ultimately be executed. The trials have been the subject of much study and debate, and are seen as a cautionary tale about the dangers of hysteria and intolerance.

4. On April 6, 1886, the iconic Parker House Hotel opened in Boston. The hotel was designed by renowned architect John Chandler Bancroft, and quickly became a popular destination for politicians, celebrities, and other high-profile guests. It is perhaps most famous for its role in the creation of the Boston cream pie, which was invented by one of the hotel's chefs in the mid-19th century.

5. The Massachusetts State House, one of the state's most recognizable landmarks, was dedicated on April 6, 1798. The building, which sits atop Beacon Hill in Boston, was designed by architect Charles Bulfinch, and is widely considered a masterpiece of early American architecture. Today, the State House serves as the seat of the Massachusetts government, and is open to visitors for guided tours and other events.