1. On June 16, 1903, the Dayton Wright Company was established in Dayton, Ohio by Wilbur and Orville Wright. The company would go on to become one of the leading manufacturers of aircraft during World War I.

2. In 1954, the Cleveland Indians became the first major league baseball team to feature an all-African American outfield, with Larry Doby, Al Smith, and Dave Pope. They played together for the first time on June 16, 1954.

3. On June 16, 2015, Ohio Governor John Kasich signed a bill legalizing medical marijuana in the state. The law allowed patients with qualifying medical conditions to use marijuana for medical purposes, but also set strict guidelines for its use and distribution.

4. In 1805, General Anthony Wayne led his troops to victory over a Native American coalition in the Battle of Fallen Timbers, which took place near what is now Toledo, Ohio. This battle solidified American control over the area and opened up the Northwest Territory to further settlement.

5. On June 16, 1961, Ohio astronaut Neil Armstrong became the first civilian to fly into space when he piloted the X-15 rocket plane to an altitude of 207,500 feet. Armstrong would later go on to become the first human to set foot on the moon in 1969 during the Apollo 11 mission.