1. On June 22, 1861, Mississippi voted to secede from the United States and join the Confederate States of America, becoming the second state to do so after South Carolina. This decision marked the beginning of the Civil War.

2. On June 22, 1937, the state of Mississippi officially adopted the flag that is known as the "Magnolia Flag." The flag features a magnolia tree and a red, white, and blue color scheme, and was flown until it was replaced by the current Mississippi state flag in 1894.

3. On June 22, 1964, civil rights workers Andrew Goodman, James Chaney, and Michael Schwerner went missing while investigating the burning of a black church in Neshoba County, Mississippi. Their bodies were discovered 44 days later, and their murders are considered one of the key events in the Civil Rights Movement.

4. On June 22, 1987, the Supreme Court of the United States ruled in Edwards v. Aguillard that a Louisiana law requiring that creationism be taught alongside evolution in public schools was unconstitutional. The ruling had significant implications for the teaching of creationism and evolution in schools across the country.

5. On June 22, 2020, Mississippi Governor Tate Reeves signed a bill that removed the state flag, which included the Confederate battle emblem, and replaced it with a new design featuring a magnolia flower and the state motto, "In God We Trust." The move was widely praised as a step toward racial justice and unity in the state.