1. On March 12, 1780, during the American Revolution, British forces led by Lieutenant Colonel Banastre Tarleton defeated American troops under the command of General Isaac Huger at the Battle of Wetzel's Mill in Berkeley County.

2. The University of South Carolina was founded on March 12, 1801, when the South Carolina General Assembly passed an act to establish a state-supported college in Columbia.

3. On March 12, 1865, during the Civil War, Union forces under Major General William T. Sherman occupied the city of Columbia, the capital of South Carolina.

4. The first-ever Charleston Fashion Week, a popular event that showcases emerging designers, models, and brands, began on March 12, 2007.

5. On March 12, 2020, South Carolina Governor Henry McMaster declared a state of emergency due to the COVID-19 pandemic.