1. In 1836, the South Carolina College (now known as the University of South Carolina) was forced to close for two years due to financial troubles caused by the Panic of 1837.

2. On March 21, 1865, Confederate General Joseph E. Johnston was appointed as commander of all Confederate forces in the Carolinas during the American Civil War.

3. In 1903, the South Carolina General Assembly passed a law prohibiting the teaching of evolution in public schools, which led to the famous Scopes Monkey Trial in Tennessee in 1925.

4. On March 21, 1942, Charleston native and World War II hero Doris Miller became the first African American to be awarded the Navy Cross for his actions during the attack on Pearl Harbor.

5. In 1960, the South Carolina State House was designated a National Historic Landmark, recognizing its significance as an example of the state's antebellum architecture and for its role in South Carolina's government and history.