1. On March 22, 1898, the Missouri Legislature passed a bill establishing the first state normal school in Missouri. This school eventually became Missouri State University, which is now a comprehensive university located in Springfield.

2. Missouri's only Civil War battle in which African-American soldiers played a significant role took place on March 22, 1864, near Camden Point. The battle resulted in a Confederate victory, with the Union forces retreating to Fort Leavenworth.

3. The St. Louis Cardinals played their first game at brand new Busch Stadium III on March 22, 2006, defeating the Cleveland Indians 5-1 in an exhibition game. The Cardinals went on to win the World Series in that same season.

4. On March 22, 1894, Benjamin "Pap" Singleton, a former slave and prominent African-American leader, died in Kansas City. Singleton was a leader in the "Exoduster" movement, which encouraged African Americans to move from the South to the Midwest in search of better economic opportunities and freedom.

5. The Missouri General Assembly passed a law on March 22, 1875, officially declaring the mule the official state animal of Missouri. This was in recognition of the key role that mules played in the state's agricultural economy at the time.