1. Arizona achieved statehood on November 21, 1912, becoming the 48th state in the United States. Arizona's admission came after a long and tumultuous struggle for statehood that began in the late 1800s.

2. On November 21, 1985, actor and Arizona resident John Wayne passed away at the age of 72 after a battle with cancer. Wayne, who starred in more than 170 films over his long career, was a beloved figure in Arizona and is remembered as one of Hollywood's greatest icons.

3. The annual Tucson Meet Yourself festival, which celebrates the cultural diversity of Tucson and southern Arizona, typically takes place over the third weekend in October, but it was moved to November 21-22 in 2020 due to the COVID-19 pandemic. The festival features food, music, dance, and crafts from more than 50 different cultural groups.

4. On November 21, 1958, a Boeing B-47 Stratojet bomber crashed into a residential neighborhood in Tucson, killing all four crew members on board and one person on the ground. The cause of the crash was determined to be a malfunctioning engine, and the incident led to increased safety measures for military aircraft.

5. In 2018, Arizona Senator Jon Kyl, who served in the Senate from 1995 to 2013 and was appointed to fill the seat left vacant by the death of Senator John McCain, announced that he would once again be resigning from the Senate, effective December 31 of that year. Kyl's announcement on November 21, 2018, set off speculation about who Arizona Governor Doug Ducey would appoint to fill the seat until a special election could be held.