1. On November 21, 1871, Mary Eliza Mahoney became the first African American to graduate from the New England Hospital for Women and Children's nursing program. Mahoney went on to have a successful career as a professional nurse and advocate for the advancement of African American women in the nursing profession.

2. November 21, 1969, was a significant day for women's rights in Massachusetts, as the state's legislature held a joint session to ratify the Equal Rights Amendment to the US Constitution, which would guarantee equal legal rights for all citizens regardless of gender.

3. On November 21, 1970, the luxury ocean liner SS France made its final voyage to Boston Harbor before being retired from service. The ship was a symbol of French engineering and cultural pride, and its arrival was accompanied by much fanfare and celebration.

4. November 21, 1620, is the approximate date that the Pilgrims aboard the Mayflower landed at what is now Plymouth, Massachusetts. The subsequent settlement of Plymouth Colony would become a foundational moment in American history and a focal point of the state's cultural legacy.

5. In 2005, November 21 was designated National Adoption Day in Massachusetts, recognizing the important role that adoption plays in the lives of thousands of families across the state. The day is marked by events and ceremonies celebrating the joy and love that comes with the adoption process.