1. The First American Medical College for Women was established in Ohio on November 21, 1848. The medical college aimed to provide women with medical education, which was not available to them at that time in most parts of the country.

2. On November 21, 1938, Cleveland Municipal Stadium hosted its first professional football game, between the Browns and the Chicago Bears. The Browns won the game 13-3, and the stadium went on to host many other important sporting events, including two World Series and an NFL Championship game.

3. November 21, 1969, saw the completion of the Neil Armstrong Air and Space Museum in Wapakoneta, Ohio. Neil Armstrong, the first person to walk on the moon, was born in Wapakoneta, and the museum is dedicated to his achievements in space exploration.

4. Ohio's first official state song, "Beautiful Ohio," was adopted on November 21, 1969. The song, which was written by Ballard MacDonald and composed by Robert A. King, celebrates the natural beauty of Ohio, particularly its rolling hills and winding rivers.

5. On November 21, 2016, the Ohio State Buckeyes men's basketball team gained national attention with a 77-69 upset of the then-No.2-ranked team in the country, the Duke Blue Devils. The victory was especially sweet for Buckeyes coach Thad Matta, who spent two seasons as an assistant coach at Duke early in his career.