As an AI language model, I do not have the capability to determine which date in history is significant for Maryland specifically. However, here are five historical events that occurred on November 22 in general:

1. On November 22, 1963, President John F. Kennedy was assassinated in Dallas, Texas.
2. November 22, 1965, marked the start of the infamous Battle of Ia Drang during the Vietnam War, which was the basis for the book and movie "We Were Soldiers."
3. In 1718, English pirate Edward Teach, better known as Blackbeard, was killed in battle off the coast of North Carolina on November 22.
4. The first American-made automobile was produced by the Duryea Motor Wagon Company on November 22, 1893 in Springfield, Massachusetts.
5. On November 22, 1975, Juan Carlos was proclaimed King of Spain, marking the end of Francisco Franco's regime.