1. On November 22, 1789, North Carolina became the 12th state to ratify the U.S. Constitution, solidifying its place in the newly formed United States of America.

2. In 1898 on November 22, Wilmington, North Carolina experienced a violent coup d'etat known as the Wilmington Race Riot, which resulted in the forced resignation of the city's black mayor and the establishment of white supremacist rule.

3. November 22, 1945 marked the founding of the University of North Carolina School of the Arts, a conservatory-style institution that offers undergraduate and graduate degrees in the arts.

4. On November 22, 1956, the North Carolina Symphony made its debut performance at Duke University Chapel in Durham, North Carolina, marking the beginning of what would become the state's most renowned orchestral ensemble.

5. November 22, 1963 was the fateful day that President John F. Kennedy was assassinated in Dallas, Texas. North Carolina played a small but significant role in the aftermath of the tragedy, as Lee Harvey Oswald's mother resided in the small town of New Bern and the first photograph of Oswald after the assassination was taken at a bus station in Raleigh.