1. On November 22, 1945, East Tennessee State College (now East Tennessee State University) was officially founded. The college, located in Johnson City, offers a variety of undergraduate and graduate programs.

2. In 1963, President John F. Kennedy was assassinated in Dallas, Texas, and his body was later transported to Washington D.C. for a state funeral. A memorial service was held in Knoxville, Tennessee, on November 22, which was attended by thousands of mourners.

3. On November 22, 1890, the Cumberland Telephone and Telegraph Company was incorporated in Nashville, Tennessee. The company provided telephone and telegraph services throughout the region and played a key role in the development of communications infrastructure in the state.

4. The Tennessee Valley Authority (TVA), a federally owned corporation that provides power and other services to the Tennessee Valley region, was established on November 22, 1933. The TVA operates hydroelectric facilities, manages flood control systems, and promotes economic development in the region.

5. On November 22, 1987, the Great Smoky Mountains National Park in Tennessee and North Carolina was designated a UNESCO World Heritage site. The park is known for its scenic beauty, diverse wildlife, and rich cultural history, and attracts millions of visitors each year.