1. Mark Twain was born on November 28, 1835 in Florida, Missouri. He went on to become one of the most well-known American authors, penning classics such as Adventures of Huckleberry Finn and The Adventures of Tom Sawyer.

2. Nov. 28, 1861 marked the date of the Battle of Cane Hill, a Civil War engagement in Washington County, MO. Confederate forces under the command of General Sterling Price were defeated by Union troops, causing them to abandon their efforts to invade Missouri.

3. On November 28, 1944, a tragic explosion occurred at the Naval Ammunition Depot in St. Louis, Missouri, killing 22 people and injuring dozens more. The explosion was caused by a fire in one of the depots, which contained high explosives.

4. The University of Missouri's first African-American graduate, Lloyd Lionel Gaines, disappeared on November 28, 1939, shortly after winning a Supreme Court case that allowed him to attend the university’s law school. His disappearance remains a mystery, and his case drew national attention to the issue of segregation in education.

5. On November 28, 1821, Missouri officially became a state, becoming the 24th state to join the Union. Its statehood was controversial due to the issue of slavery, and in the lead-up to the Civil War it became a battleground state for the debate between pro-slavery and anti-slavery forces.