1. Indiana admitted to the Union: On November 29, 1816, Indiana became the 19th state to be admitted to the Union. The Hoosier State was home to some of the earliest settlers in the United States, with Native American tribes such as the Miami and Potawatomi being among the first inhabitants.

2. US Presidents with Indiana connection: Two US Presidents have a connection to Indiana. The first is William Henry Harrison, who served as the ninth President of the United States in 1841. Harrison was born in Virginia, but he moved to Indiana in 1800 and lived there for 12 years. The second President with a connection to Indiana is Abraham Lincoln, who spent part of his childhood living in Spencer County.

3. Indiana University founded: On November 29, 1820, Indiana University was founded in Bloomington. The university is the flagship institution of the Indiana University system and is widely regarded as one of the top public universities in the United States.

4. Eddie Mathews born: On November 29, 1931, baseball legend Eddie Mathews was born in Texarkana, Texas. Mathews played for four different teams during his 17-year career, including the Milwaukee Braves, where he won a World Series championship in 1957. Mathews was inducted into the Baseball Hall of Fame in 1978.

5. Pfizer vaccine approved: On November 29, 2020, the Pfizer-BioNTech COVID-19 vaccine was granted emergency use authorization by the US Food and Drug Administration. The vaccine was the first COVID-19 vaccine to be authorized for emergency use in the United States and has since been widely distributed throughout the country.