1. Missouri Territory was created on November 6, 1812: President James Madison signed the bill that officially created the Missouri Territory on this date. The territory would eventually become the state of Missouri when it was admitted to the Union in 1821.

2. The first commercial flight in Missouri took place on November 6, 1914: The flight was conducted by Tony Jannus, who flew a Benoist Type XIV flying boat from Kinloch Field in St. Louis to Chicago. This was the first regularly scheduled commercial airline route in the world.

3. The United States Supreme Court upheld the legality of contraception on November 6, 1961: In the landmark case of Griswold v. Connecticut, the Supreme Court ruled that a state's ban on the use of contraception violated the right to marital privacy.

4. Missouri voters approved a constitutional amendment banning same-sex marriage on November 6, 2004: The amendment defined marriage as being between one man and one woman. However, the decision was later overturned by the United States Supreme Court in 2015 in the case of Obergefell v. Hodges.

5. The Missouri Tigers football team played its first game on November 6, 1890: The Tigers defeated the Missouri School of Mines and Metallurgy by a score of 7-0. Missouri would go on to become one of the most successful football programs in college football history.