1. On October 21, 1837, the Battle of Brushy Creek took place in Mississippi. It was a conflict between Choctaw Indians and American settlers that resulted in the deaths of several Native Americans.

2. In 1909, the first automobile race in Mississippi was held on October 21. It took place at the State Fairgrounds in Jackson, and the winner received a cash prize of $500.

3. On October 21, 1960, the first African American student, James Meredith, enrolled at the University of Mississippi. This event sparked a riot on campus and led to the involvement of federal troops to secure his admission.

4. In 1985, Hurricane Juan struck Mississippi on October 21. It was one of the deadliest hurricanes to hit the state and resulted in the loss of at least 13 lives and extensive damage to property.

5. On October 21, 2013, the Mississippi National Guard opened a new Joint Force Headquarters at Camp Shelby. The building, which serves as the primary command and control center for the state's National Guard forces, cost $20 million to construct.