1. On October 21, 1780, the Battle of Fishdam Ford was fought during the American Revolutionary War. British forces led by Major James Wemyss clashed with American troops commanded by Brigadier General Thomas Sumter near the Broad River in what is now Fairfield County. Despite being outnumbered, the Americans successfully defended their position and forced the British to retreat.

2. John C. Calhoun, a prominent South Carolina politician and statesman, was born on October 21, 1782. Calhoun served as vice president of the United States under both John Quincy Adams and Andrew Jackson, and was a leading advocate for states' rights and nullification during the Antebellum era.

3. The University of South Carolina was chartered on October 21, 1801. Originally founded as South Carolina College, the institution is the flagship university of the state and has a rich history of academic excellence and athletic achievements.

4. On October 21, 1954, Hurricane Hazel made landfall in South Carolina, causing widespread damage and claiming the lives of at least 11 people. The storm is considered one of the most catastrophic hurricanes to hit the state, and prompted significant changes in emergency response and preparedness.

5. In 1983, South Carolina Governor Richard Riley signed legislation establishing the South Carolina Aquarium Foundation. The organization, which operates the South Carolina Aquarium in Charleston, is dedicated to promoting ocean conservation and education, and has become a popular attraction and educational resource in the state.