1. In 1746, a devastating fire broke out in Boston's North End, destroying more than 300 buildings and leaving thousands homeless.
2. On October 22, 1794, the first Baptist church in Boston was dedicated, marking a significant moment in the history of religious freedom in the city.
3. Massachusetts native John F. Kennedy delivered a historic speech at the Massachusetts State House on October 22, 1962, in which he declared that the United States would not tolerate missile sites in Cuba.
4. In 2000, the Boston Red Sox won their first American League pennant in 14 years, defeating the New York Yankees in an unforgettable Game 5 of the ALCS.
5. On October 22, 2020, Massachusetts legalized the use of marijuana for medicinal purposes, becoming the 17th state in the country to do so.