1. On September 21, 1863, the Battle of Fisher's Hill was fought in Wood County, West Virginia during the Civil War. Union forces under General William Averell defeated Confederate forces commanded by General Albert G. Jenkins, securing control of the region around Parkersburg.

2. September 21, 1889 is significant for the state of West Virginia, as it marks the date when the state's constitution was ratified, officially making it the 35th state of the United States.

3. On September 21, 1897, coal miners in the town of Poca, West Virginia went on strike in protest of poor working conditions and low wages. The strike lasted for several months and resulted in violent clashes between strikers and law enforcement officers.

4. In 1935, on September 21, the West Virginia capitol building in Charleston was dedicated. The building, which took eight years to construct, is made of Indiana limestone and features a striking gold-plated dome that is visible from miles away.

5. September 21, 1976 saw the tragic death of two members of the band Lynyrd Skynyrd in a plane crash near Gillsburg, Mississippi. One of the victims, guitarist Steve Gaines, was a native of Seneca Rocks, West Virginia, and the town hosts an annual tribute concert in his memory.