1. On September 22, 1780, American forces led by General Nathanael Greene engaged in a significant battle against the British Army at Fishing Creek in South Carolina. Despite being outnumbered, Greene's army was able to cause significant damage to the British forces and delay their advance into North Carolina.

2. On September 22, 1862, Confederate forces under General Braxton Bragg attacked Union troops under General Don Carlos Buell at the Battle of Perryville in Kentucky. Although the Confederates were initially successful, the Union army was ultimately able to hold their ground and prevent the Confederate army from advancing any further north.

3. On September 22, 1902, physicist and inventor Edwin Herbert Hall was born in Great Falls, Maine. Hall is best known for his discovery of the Hall effect, a phenomenon in which an electric current moving through a conductor creates a magnetic field perpendicular to the current.

4. On September 22, 1952, South Carolina Governor James F. Byrnes ordered the National Guard to enforce segregation at Clemson College (now Clemson University), which had recently admitted its first black student. This led to a legal battle that ultimately ended with the desegregation of the school in the 1960s.

5. On September 22, 1989, Hurricane Hugo made landfall near Charleston, South Carolina, causing widespread damage and destruction throughout the state. The storm, which was the strongest hurricane to hit the state in more than a century, caused more than $7 billion in damage and resulted in 35 deaths.