1. On September 22, 1862, two battles took place in South Dakota during the Dakota War of 1862. The Battle of Big Mound and the Battle of Birch Coulee saw clashes between the United States Army and Dakota warriors.

2. South Dakota became a state on November 2, 1889, but on September 22 of that year, the territorial legislature met for the first time in the newly constructed capitol building in Pierre.

3. In 1938, President Franklin D. Roosevelt visited Badlands National Park in South Dakota on September 22, making him the first sitting president to visit the park.

4. On September 22, 1972, the Oglala Sioux Tribe declared war on the United States government in protest of the government's treatment of Native Americans. The conflict lasted for 71 days and resulted in the deaths of two FBI agents and one Native American.

5. In 2013, an F3 tornado touched down near the town of Wessington Springs on September 22, causing extensive damage to the area. Despite the strength of the tornado, there were no reported fatalities.