1. On September 6, 1864, the Battle of Athens took place in Limestone County during the American Civil War. Union troops under General Robert S. Granger defeated Confederate forces led by General Stephen D. Lee.

2. On September 6, 1920, the first airplane mail route in the United States was established between New York City and San Francisco, with a stop in Birmingham, Alabama.

3. On September 6, 1965, the University of Alabama admitted its first African-American students, Vivian Malone and James Hood, following the intervention of the federal government.

4. On September 6, 1992, Hurricane Andrew made landfall in southeastern Louisiana, causing significant damage in nearby Mobile and Baldwin Counties in Alabama.

5. On September 6, 2013, a fire destroyed the historic Lee County Courthouse, which had stood in Opelika since 1903. The building had been listed on the National Register of Historic Places.