1. On September 6, 1839, the first recorded college football game was played between Amherst College and Williams College in Pittsfield, Massachusetts. The game was played with modified English rugby rules and resulted in a scoreless tie.

2. September 6, 1910, marks the date of the deadliest factory fire in U.S. history, known as the Great Fire of 1910. The blaze at the Shoe and Leather Corporation in Brockton claimed the lives of 58 workers, most of whom were women and children.

3. On September 6, 1990, the Big Dig groundbreaking ceremony was held in Boston, officially marking the start of the massive infrastructure project. The project, which aimed to reroute I-93 underground and create more green space above, took 15 years to complete and cost over $21 billion.

4. In 1620, the Mayflower set sail from Plymouth, England, on September 6, with around 100 passengers on board, including the Pilgrims who would go on to found the Plymouth Colony in Massachusetts.

5. September 6, 2018, marked the 350th anniversary of the Great Fire of 1668, which destroyed much of Boston's downtown area. To commemorate the event, a fireboat was dedicated and a series of events were held throughout the city.