1. On April 21, 1781, the Battle of Hobkirk's Hill took place in South Carolina during the Revolutionary War. Patriots and British forces clashed in a skirmish that resulted in 25 American and 69 British casualties.

2. The first successful human-to-human heart transplant in the United States was performed on April 21, 1967, by Dr. Christiaan Barnard at the Medical University of South Carolina in Charleston. The recipient survived for 18 days before dying of pneumonia.

3. On April 21, 1836, the Battle of San Jacinto was fought in Texas during the Texas War of Independence. South Carolinian James Butler Bonham was one of the Texian heroes who died in the battle that secured Texas's independence from Mexico.

4. The first African American woman to serve in the South Carolina General Assembly, Juanita Goggins, was born on April 21, 1934, in Union. She was elected to the State House of Representatives in 1974 and served until her death in 1980.

5. On April 21, 1865, the Civil War came to an end in South Carolina with the surrender of Confederate General Joseph E. Johnston to Union General William T. Sherman at Bennett Place in Durham, North Carolina. The surrender effectively ended hostilities in the Eastern Theater and led to the eventual reunification of the country.