1. On April 22, 1861, South Carolina became the first state to secede from the Union, leading to the start of the American Civil War.

2. On April 22, 1884, the first college football game was played in the South between Furman University and the Wofford College. Furman won the game, which was played in Greenville, South Carolina with a score of 14-6.

3. On April 22, 1915, the German submarine U-27 sank the British steamer SS Nyanza off the coast of South Carolina, marking the first time that a submarine had successfully attacked and sunk a merchant vessel on the east coast of the United States during World War I.

4. On April 22, 1947, South Carolina native and future Hall of Fame baseball player Jackie Robinson broke the color barrier in Major League Baseball by playing his first game for the Brooklyn Dodgers.

5. On April 22, 2010, an explosion on the Deepwater Horizon drilling rig in the Gulf of Mexico killed 11 people and caused a massive oil spill that affected South Carolina's coastal environment and economy. The spill was one of the worst environmental disasters in U.S. history.