1. In 1865, Union General William T. Sherman met and conferred with Confederate General Joseph E. Johnston in Fayetteville, North Carolina. This meeting would eventually lead to the surrender of Johnston's army and effectively end the American Civil War.

2. On March 6, 1905, Governor Duncan Clinch Heyward signed a bill creating the Clemson Agricultural College of South Carolina, which would later become Clemson University.

3. In 1956, a grand jury in Clarendon County indicted 20 African American activists, including the Reverend Joseph A. DeLaine and future Supreme Court justice Thurgood Marshall, for organizing a school desegregation lawsuit. The case, Briggs v. Elliott, would eventually become part of the landmark Brown v. Board of Education Supreme Court decision.

4. South Carolina Governor Robert E. McNair proclaimed March 6, 1969 as "James F. Byrnes Day" in honor of the former governor, senator, and Supreme Court justice who was born on that day in 1882.

5. On March 6, 2000, the South Carolina National Guard was activated to assist with disaster relief efforts in the aftermath of tornadoes and severe storms that swept through the state, causing widespread damage and several fatalities.