1. On November 21, 1868, the infamous "Fetterman Massacre" occurred in northeastern Wyoming. Captain William J. Fetterman and his men were ambushed and killed by a group of Lakota Sioux and Cheyenne warriors.

2. November 21, 1900, marked the opening of the first oil refinery in Wyoming, the Casper Refinery. This event marked a significant turning point in the state's economy and helped establish Wyoming as a major producer of oil and gas.

3. On November 21, 1927, legendary Western performer and rodeo champion Tom Horn was hanged in Cheyenne for the murder of a young boy. Horn's trial was controversial, and many believed he was falsely accused and executed.

4. November 21, 1934, saw the establishment of Grand Teton National Park in northwestern Wyoming. The park features stunning mountain peaks, pristine lakes and rivers, and a diverse array of wildlife.

5. On November 21, 1949, the Wyoming Territorial Prison in Laramie closed its doors for the last time. The prison had been in operation for over 50 years and was home to many notorious criminals, including Butch Cassidy. Today, the prison is open to visitors as a museum.